Further testing will be necessary to determine which of these disorders is causing the globulin levels to rise so adequate treatment can be administered. High blood protein is not a specific disease or condition in itself, but it might indicate you have a disease. High globulin levels. Those with high globulin levels may be suffering from leukemia or other bone marrow disorders, autoimmunity diseases such as lupus or collagen diseases, chronic inflammatory diseases such as syphilis, waldenstrom's macroglobulinemia, liver disease, Rheumatoid arthritis, ulcerative colitis, kidney disease or a chronic viral or bacterial infection. High blood protein (hyperproteinemia) is an increase in the concentration of protein in the bloodstream.This is also a sign that proteins taken in by the digestive system are not being broken down or absorbed properly. Renal disease, hepatic dysfunction, celiac disease, inflammatory bowel disease (IBD) and acute hemolytic anemia can cause the globulin levels to drop. Low Globulin Levels. If the globulin levels fall below this normal range it can be a sign of several serious health conditions.This should be comprised approximately of 3.5-5 gm/dL of albumin and 2.3-3.5 gm/dL of globulin. Ideally, this level will fall at 7.5 g/dL. Tests will be used to determine the specific levels of different types of globulin in the blood stream. Medications can then be used to help return the globulin levels to the normal stage to avoid any potential dangers. Medical examinations must be done to determine if the globulin levels are where they should be, and what might be causing them to be lower or higher than normal. If these proteins are not kept at the proper ration, it can be difficult for the body to properly fight infection, clot or transport nutrients to the muscles, leading to health difficulties for the patient. A high A/G ratio suggests underproduction of immunoglobulins (as may be seen in some genetic deficiencies and in some leukemias). Your globulin levels will affect the amount of ample proteins in the blood stream. If the globulin level in the blood is abnormal it can lead to health trouble. Globulins are a group of proteins in the blood stream that help to regulate the function of the circulatory system. Whether testing AG ratio is cost effective to predict failure mortality warrants further investigation.Want to get this tested? order a health assessment today Since total protein and globulin concentrations were elevated, they may be a marker of chronic systemic inflammation and may serve to be a powerful predictor of mortality. Conclusions: A low AG ratio in chronic heart failure patients is associated with high 6 and 12 month mortality. A low AG ratio was observed in higher BMI, advanced age and elevated transaminases. Furthermore, group 1 had higher concentrations of globulin and total proteins and lower albumin concentration. Free light chains (kappa, lambda, kappa/lambda ratio) Small protein chains produced by plasma cells, a type of white blood cell that makes large amounts of a specific antibody that fights bacteria and viruses. We divided patients in to two groups as outlined below based on AG ratio of less or greater than 1.1. For mortality data source, we linked our cohort from electronic medical records with updated mortality data. Thus, a ratio of less than 0.2 is equivalent to 0.2 g of protein per day and is considered normal, a ratio of 3.5 is equivalent to 3.5 g of protein per day and is considered nephrotic-range (or. Cox proportional hazards models were developed to estimate the association between AG ratio and mortality endpoints. Thus, subsequent analyses were restricted to 6- and 12-month mortality. An early divergence of the survival curves was observed within approximately 12 months from baseline with little additional divergence thereafter. Kaplan-Meier survival estimates were calculated at every tenth of a year and plotted over five years by AG group. Methods: We studied a retrospective cohort of 13,117 unique patients within our clinical database at Geisinger Health System between Januand Dec 31, 2013. We sought to determine whether alterations in the albumin globulin (AG) ratio were associated with mortality in stable heart failure patients. Yet its association with stable heart failure patients has not been well understood. Globulin, the other major serum protein group, is a marker of inflammation that is altered in heart failure state. Introduction: Heart failure (HF) is associated with low serum albumin and has a linear relationship with mortality.
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